ASCO: Enhertu’s Empire Expands

Jun 03 2024

• By Elizabeth Cairns

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“Transformative” data could move Daiichi Sankyo and AstraZeneca’s conjugate into ultralow HER2 expressers, and allow its use ahead of chemo in breast cancer.

Dividing breast cancer cell

Two years ago data from the DESTINY-Breast04 trial, testing Enhertu in breast cancer patients with low HER2 expression, prompted a standing ovation from delegates at the American Society of Clinical Oncology annual meeting. At this year’s ASCO the product proved its worth in an earlier setting and in patients with even lower levels of the antigen, and this presentation too was greeted with applause. (Also see "ASCO: AstraZeneca's Enhertu Is Poised To Change The Breast Cancer Paradigm" - Scrip, 6 June, 2022.)

Key Takeaways

Data from the DESTINY-Breast06 trial will probably allow Enhertu to be used ahead of chemotherapy in both HER2-low and -ultralow breast cancer patients.

The DESTINY-Breast06 data, presented yesterday, are indeed impressive. In patients with low expression of HER2, the protein to which Enhertu...

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