AstraZeneca And Daiichi Get Low

 
• By Elizabeth Cairns
  
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A hit with Enhertu in an earlier setting in HER2-low breast cancer patients, and in ultralow expressers, heightens expectations.    

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The long-awaited topline success of Daiichi Sankyo Co., Ltd. and AstraZeneca PLC’s DESTINY-Breast06 trial of their antibody-drug conjugate Enhertu is significant twice over. Firstly it could allow the product to move ahead of chemotherapy in breast cancer patients with high or low expression of HER2, for whom it is already largely established as standard-of-care post-chemo.

Key Takeaways

  • The DESTINY-Breast06 study of AstraZeneca And Daiichi Sankyo’s Enhertu has shown a meaningful and significant benefit when used ahead of chemo in patients with HER2-low metastatic breast cancer

Secondly, it could expand into a whole new population: those whose tumors express HER2 at ultra-low levels. But a great...

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