Next-Generation BCMA-Targeting CAR-T Therapy Results To Date
	Response Rates	CRS And Neurotoxicity
ALLO-715 (Allogene)	At a 30 October cutoff, 35 patients were enrolled in the Phase I study, 31 were evaluable for safety and 29 were evaluable for efficacy across four doses. At the third highest dose of 320 million cells six out of 10 patients responded for an ORR of 60% and four achieved very good partial response (VGPR) or better; VGPR-plus was defined as VGPR, CR or stringent CR (sCR).	There were 14 cases of CRS (45%) but all were grade 1 (n=5; 16%) or grade 2 (n=9; 29%). No immune effector cell-associated neurotoxicity syndrome (ICANS) was observed.
P-BCMA-101 (Poseida)	Among six people treated with a 750,000 cell/kg dose of P-BCMA-101 manufactured with the nanoplasmid process, four patients responded (ORR=67%) and three patients (50%) achieved a VGPR or CR. The ORR was 50% among four patients treated at this dose manufactured with the prior process.	Poseida reported safety for 53 patients treated with P-BCMA-101 across doses and both manufacturing processes in its ongoing Phase I dose-escalation study. Nine patients developed CRS (17%) with no grade 3 or higher cases. Two patients (3.8%) experienced neurotoxicity; both were grade 3 adverse events.
bb21217 (BMS/bluebird)	Data from 69 patients treated in the ongoing Phase I trial show a 68% ORR with 17 patients (29%) achieving CR or sCR and 15 VGPRs (25%).	CRS occurred in 48 patients (70%), including one grade 3 (1%) and two grade five (3%) events. Eleven patients (16) had neurotoxicity, including two grade 3 (3%) and one grade 4 (1%) event.
C-CAR088 (CBMG)	Data from four patients treated at four sites in China show a 95.7% ORR (n=22) with 10 patients achieving CR or sCR (44%), 11 with VGPR (48%) and one partial response (PR; 4%).	CRS was observed in 21 patients (91.3%), but only one patient had grade 3 or higher CRS (4.3%). One patient experienced neurotoxicity (4.3%) but it was mild and resolved in one day.
GC012F (Gracell)	Sixteen patients were enrolled in a Phase I investigator-initiated clinical trials as of 17 July across three dose levels. The ORR was 93.7% and all six patients at the highest dose achieved a minimal residual disease (MRD)-negative sCR; four of these patients retained their response at six months.	Grade 1 or 2 CRS was experienced by 87.5% of patients and two additional patients had grade 3 CRS (12.5%). No ICANS was observed.
CT053 (CARsgen)	Results from 58 patients across three studies were presented. In two years of follow-up from 24 patients in China, the ORR was 87.5% and the CR/sCR rate was 79.2%. Among 20 patients treated in the Phase Ib LUMMICAR STUDY 2 in the US, the ORR was 94% for the first 18 patients with eight weeks of follow-up. The ORR was 100% for 14 patients in the Phase I LUMMICAR STUDY 1 in China.	In all three datasets, there was no grade 3 or higher CRS, but 15 patients (62.5%) had grade 1 or 2 CRS in the first dataset and 15 out of 19 patients (79%) had grade 1 or 2 CRS in LUMMICAR 2. There was no CRS-related neurotoxicity in LUMMICAR 1, but one patient (4.2%) had grade 3 neurotoxicity in the initial dataset in China and three patients (15.8%) had ICANS in LUMMICAR 2, including one grade 3 ICANS event (5.3%).
CART-ddBCMA (Arcellx)	All six patients treated at the first dose level of 100 million cells in Arcellx’s Phase I study responded to treatment and four (67%) achieved sCR and there were two PRs (33%).	All six patients had grade 1 or two CRS and one had grade 1 or 2 neurotoxicity.
Sources: Company reports, ASH presentations, William Blair, Bernstein

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