Poseida, Legend/Janssen Look To Snag Celgene/Bluebird's BCMA Crown

 
• By Mandy Jackson
  
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Poseida and Legend/Janssen aim to develop CAR-T therapies with improved efficacy and safety, and both programs delivered updates at ASH for BCMA-targeting CAR-T candidates in multiple myeloma that could challenge Celgene/bluebird's lead in this field.

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While Celgene Corp. and bluebird bio Inc. have the most advanced BCMA-targeting chimeric antigen receptor T-cell (CAR-T) therapy in the clinic for the treatment of relapsed or refractory multiple myeloma, data presented at the American Society of Hematology (ASH) meeting on Dec. 3 in San Diego show that CAR-T therapies against the same target from Poseida Therapeutics Inc., partners Legend Biotech Corp. and Janssen Pharmaceutical Cos., and others are quickly gaining ground.

Early Phase I data showing strong responses in the first 12 patients treated with Celgene's and bluebird's bb21217 – the...

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