Cartesian Looks To Chart The Way For CAR-T In Autoimmune Disease

 
• By Jessica Merrill
  
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A Phase IIb trial testing Cartesian’s autologous mRNA-engineered CAR-T therapy for the treatment of generalized myasthenia gravis (MG) met the primary endpoint.

autoimmune disease
Cartesian announced clinical trial data for a CAR-T in autoimmune disease. • Source: Shutterstock

Cartesian Therapeutics, Inc. has positive data from a Phase IIb trial testing Descartes-08, an autologous mRNA-engineered chimeric antigen receptor T-cell (CAR-T) therapy directed against the B-cell maturation antigen (BCMA) in patients with generalized myasthenia gravis (MG), positioning the company at the forefront of development of CAR-T therapeutics for autoimmune disease.

Key Takeaways

  • A Phase IIb trial testing Descartes-08, an autologous mRNA-engineered CAR-T therapy in patients with generalized myasthenia gravis (MG), was positive.

The trial represents the first placebo-controlled study of a CAR-T cell therapy in autoimmune disease to the best of Cartesian’s...

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