Mustang Bio’s MB-101 Gallops To Win In Glioblastoma

Mar 07 2024

• By Alaric DeArment

Listen to this article

The lead author on the Phase I study told Scrip that in addition to targeting a widely expressed antigen on GBM tumors, the CAR-T also stimulates the body’s immune system.

• Source: Shutterstock

Two of the reasons why glioblastoma multiforme (GBM) has proven one of the toughest cancers in oncology – being incurable, invariably fatal and with a median overall survival (OS) of two years or less – are its heterogeneity in terms of antigen expression and the difficulty of getting drugs across the blood-brain barrier. But Mustang Bio Inc.’s CAR-T cell therapy MB-101 has managed to get past both hurdles to achieve a significant improvement in OS among patients with recurrent GBM.

Mustang and City of Hope Comprehensive Cancer Center, which originally developed the cell therapy, announced the publication of data from...

More from Immuno-oncology

Allarity Hopes To Breathe New Life Into Ixempra In Breast Cancer
Sep 24 2025
The US precision medicine company hopes its drug response predictor technology will enhance responses to the chemotherapy Ixempra on the basis of promising data from a handful of breast cancer patients in a Phase II trial, marking a positive turn in its journey to date.
What To Look Out For At ESMO 2024
Mar 10 2025
• By Alexandra Shimmings
Attendees at this year's European Society for Medical Oncology meeting in Barcelona can look forward to a range of interesting datasets, from Phase III trials of established products in new settings to preliminary studies of novel products coming through the pipeline.
As More DLL3 Bispecifics Advance, Doctors Are Adjusting To CRS, ICANS
Mar 10 2025
• By Mandy Jackson
Amgen’s Imdelltra for small-cell lung cancer is one of two bispecific T-cell engagers approved for solid tumors, but data at the WCLC meeting show other DLL3-targeting BiTEs may be on the way.
Novo Nordisk’s Semaglutide Shows Promise In Hidradenitis Suppurativa
Mar 10 2025
• By Andrew McConaghie
An academic study of GLP-1 agonist showed promise in patients with the painful skin condition but with no signs that the Danish drugmaker will pursue the indication, smaller players in the space may be interested.

More from Anticancer

Innovent/GenFleet Score China’s First KRAS G12C Inhibitor Approval
Mar 10 2025
• By Dexter Jie Yan
The nod will help unlock a national market for the partners’ Dupert (fulzerasib) in which roughly 50,000 people are expected to be newly diagnosed with lung cancer harboring the KRAS G12C mutation in 2025. Meanwhile, two other homegrown rivals are also closing in on marketing clearances in China.
Cagrisema Leads The Charge For 2025
Mar 10 2025
• By Elizabeth Cairns
2030 sales forecasts for Novo’s obesity hope are an order of magnitude larger than its closest rival among 2025’s expected debutantes.
Ordspono Will Be Regeneron’s First Independent European Launch
Mar 10 2025
• By Jessica Merrill
Ordspono, a bispecific antibody newly approved in the EU to treat follicular lymphoma and diffuse large B-cell lymphoma, joins Libtayo in Regeneron’s growing oncology portfolio.