Roivant Won’t Continue With Brepocitinib In Lupus After Phase II Failure

 
• By Joseph Haas
  
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The company wants to focus efforts with the TYK2/JAK1 inhibitor in orphan rheumatology indications like dermatomyositis where current treatment options are inadequate.

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Without SLE, Roivant has fewer indications to juggle now with brepocitinib • Source: Shutterstock

Roivant Sciences Ltd. and its subsidiary Priovant Therapeutics still have big plans for the dual TYK2/JAK1 inhibitor brepocitinib, but those plans no longer include further development in systemic lupus erythematosus. The firm said the drug, partnered with Pfizer Inc., showed a strong responder rate but also a high placebo response in a Phase II study, leaving brepocitinib difficult to evaluate in an indication Roivant was only mildly enthused about, CEO Matt Gline said in an interview.

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