Morphic Shows Potential For An ‘Oral Entyvio’ With Phase IIa Data

 
• By Joseph Haas
  
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MORF-057, addressing the same target as Takeda blockbuster Entyvio, shows efficacy and safety in ulcerative colitis. Various companies have sought an oral competitor to established biologics in UC.

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Morphic made progress in the race for an oral therapy in UC • Source: Shutterstock

Although the data are only from a small, open-label study, Morphic Therapeutic, Inc. generated excitement from shareholders and analysts on 25 April with top-line data showing its selective alpha-4 beta-7 (ɑ4β7) integrin inhibitor MORF-057 could offer similar efficacy in ulcerative colitis patients to Takeda Pharmaceutical Co. Ltd.’s injectable blockbuster Entyvio (vedolizumab), with a clean safety profile.

Morphic needed a win following the exits of AbbVie Inc. last June and Janssen Pharmaceutica Inc. in January...

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