CinCor Plans Baxdrostat Phase III Despite Phase II Miss In Uncontrolled Hypertension

 
• By Joseph Haas
  
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With subgroup analysis that it claims shows efficacy in non-Hispanics and success in a previous Phase II in treatment-resistant hypertension, CinCor plans to outline Phase III plans to FDA in early 2023.

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CinCor hopes to advance baxdrostat in hypertension despite Phase II setback • Source: Shutterstock

CinCor Pharma, Inc. has been busy raising cash on the promise of its selective aldosterone synthase inhibitor baxdrostat this year, but a missed primary endpoint in a Phase II study in uncontrolled hypertension has some investors second-guessing their decisions. However, the Waltham, MA-based firm is hoping that success in an earlier Phase II study in treatment-resistant hypertension, a prespecified subgroup analysis from the more recent study and a theory about non-adherence to background therapy might combine to support a Phase III program next year.

On 28 November, CinCor reported that baxdrostat (CIN-107), licensed from Roche Holding AG in 2019 for investigation in high...

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