Vaxcyte’s 24-Valent Pneumococcal Vaccine Shows Best-In-Class Potential

Small Biotech Hopes To Compete In Big Pharma-Dominated Market

 
• By Joseph Haas
  
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The biotech’s share price jumps more than two-thirds as analysts hail top-line Phase I/II data as better than expected. Vaxcyte hopes to hold Phase III planning discussions with the FDA in 2023.

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Vaxcyte's proof-of-concept data for its PCV candidate has company, investors excited • Source: Shutterstock

Vaxcyte, Inc. unveiled top-line Phase I/II data for its 24-valent pneumococcal conjugate vaccine (PCV) on 24 October, showing safety comparable to Pfizer Inc.’s Prevnar 20 and demonstrating non-inferiority on opsonophagocytic activity (OPA) across all 20 serotypes covered by Prevnar 20, with higher immune responses seen on 16 serotypes. VAX-24 also addresses four serotypes of invasive pneumococcal disease not covered by Prevnar 20 or any competing product and met standard superiority criteria for each in the data readout, the company said.

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