Phase III Data In Suspected NASH Boost Madrigal’s Profile, But Bigger Data To Come

 
• By Joseph Haas
  
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Resmetirom, Madrigal’s THRβ agonist, demonstrates safety and tolerability, and succeeds on secondary efficacy endpoints in a study serving as a precursor to the firm’s pivotal Phase III trial.

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Madrigal unveils additional data de-risking NASH candidate resmetirom • Source: Madrigal

Madrigal Pharmaceuticals, Inc. continued the process of de-risking Phase III non-alcoholic steatohepatitis (NASH) candidate resmetirom on 31 January, releasing positive top-line data from the Phase III MAESTRO-NAFLD-1 study in suspected NASH patients, a precursor to the biopsy-driven pivotal Phase III MAESTRO-NASH study, which is expected to report data in the third quarter of 2022.

The MAESTRO-NAFLD-1 results showed the drug’s safety and tolerability and suggested hepatic fat-reducing and LDL cholesterol-lowering capabilities on secondary endpoints.

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