Adaptimmune ‘Neck And Neck’ For First Solid Tumor T-Cell Therapy Nod For Afami-Cel

Company Looks Beyond Small Sarcoma Market For Afamitresgene Autoleucel

The company’s CEO and chief medical officer talked about some challenges as well as opportunities and what they have learned from the experience of other cell therapies.

T Cell lymphocyte with receptors for cancer cell immunotherapy research 3D render
Adaptimmune is reporting initial data from the SPEARHEAD-1 study of afami-cel at ASCO in June • Source: Shutterstock

With the potential to become the first to win US Food and Drug Administration approval for a T-cell therapy in a solid tumor indication, Adaptimmune Therapeutics plc is already thinking about how to commercialize the product, the T-cell receptor (TCR) therapy afamitresgene autoleucel. But while the initial focus will be on the tiny market for synovial sarcoma, the firm has its eye on potentially much larger markets.

The Philadelphia- and Oxfordshire, UK-based company said 19 May that it would report initial data from the pivotal Phase II...

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