Encouraging Signals For New Cancer Cell Therapy Strategies

 
• By Mandy Jackson
  
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AACR highlighted Gracell’s allogeneic CAR-T targeting CD7, Iovance’s TIL therapy in lung cancer, Gilead’s Yescarta/PD-L1 combination and the NCI’s bispecific CAR-T therapy.

t-lymphocyte. white blood cell. Lymphocyte. B-Lymphocyte. 3d illustration
Early lung cancer data were presented at AACR for Iovance's tumor-infiltrating lymphocytes • Source: Shutterstock

Chimeric antigen receptor T-cell therapies have shown remarkable efficacy in leukemia and lymphoma patients who relapsed or were refractory to several prior treatments, but many challenges remain in the cancer cell therapy field. Strategies that may improve upon first-generation therapies were presented during the American Association for Cancer Research virtual meeting with encouraging early activity, but these treatments also have hurdles to overcome.

Data from the first patients treated with novel cell therapy constructs and combinations from Gracell Biotechnologies Co. Ltd.,

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