Serious Candida Infections: Scynexis's Oral Antifungal Could Challenge Fluconazole

 
• By John Davis
  
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Positive top-line results from the Phase IIb DOVE study of Scynexis's SCY-078, and progress with a new intravenous formulation, suggest the US biotech's new triterpenoid could be the first of a new class of antifungal agents for serious infections.  

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SCY-078's results in the DOVE study were positive • Source: Shutterstock

The treatment of severe or recurrent Candida vaginal infections often relies on oral fluconazole or a handful of topical antifungal agents, a gap in the market that US biotech, Scynexis Inc., is hoping to fill with SCY-078, the first of a new class of structurally distinct glucan synthase inhibiting triterpenoids. Positive Phase IIb results in the DOVE study involving an oral formulation of the product for moderate-to-severe acute vulvovaginal candidiasis (VVC) have just been reported.

According to the Biomedtracker database, other investigational antifungal agents in development targeting glucan synthase are rare. Cidara Therapeutics Inc....

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