Cardiovascular Benefits of SGLT2 Inhibitors: A Class Effect?

 
• By John Davis
  
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The first large real-world evidence study has found SGLT2 inhibitors cut the rate of hospitalizations for heart failure and all-cause mortality in patients at low risk of cardiovascular events, but the results of CV outcomes studies are awaited to confirm the findings.

glucometer for glucose level and healthy organic food on a white background. Diabetes concept

Preliminary evidence that the cardiovascular benefits ascribed to Boehringer Ingelheim GMBH/Eli Lilly & Co.’s Jardiance (empagliflozin) may be a feature of all SGLT2 inhibitors has come from a recent real-world data analysis supported by AstraZeneca PLC, but definitive evidence still awaits a series of cardiovascular outcomes studies with individual antidiabetic agents.

The analysis of AstraZeneca’s CVD-REAL study, presented last weekend at the American College of Cardiology meeting, did not break out...

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