Tesaro Takes Lead: Ovarian Cancer PhIII Pushes Niraparib Ahead Of Clovis' PARP Inhibitor

 
• By Lucie Ellis-Taitt
  
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Positive Phase III data for Tesaro's PARP inhibitor, niraparib, have edged the drug ahead of its pipeline competitors and set the company up to give AstraZeneca's marketed therapy, Lynparza, a run for its money – but will modest PFS results be enough to convince regulators to grant a broader ovarian cancer approval for niraparib?

Racing horse
Tesaro's drug has the potential to overtake AstraZeneca's approved PARP inhibitor Lynparza • Source: Shutterstock/Ogla-i

Tesaro Inc. presented "decidedly positive" Phase III data for ovarian cancer therapy, niraparib, at the congress of the European Society for Medical Oncology (ESMO) that showed an increase in progression free survival in the maintenance setting for platinum-sensitive patients with germline BRCA mutations (gBRCA); as well as increased PFS in patients with non-gBRCA mutations and other homologous recombination deficiencies (HRDs).

Datamonitor Healthcare analyst Zachary McLellan told Scrip, "The Phase III NOVA trial data is decidedly positive for niraparib’s commercial potential...

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