Pfizer and partners pull plug on bapineuzumab for Alzheimer's after second Phase III failure

Aug 07 2012

• By Mandy Jackson

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Pfizer, Janssen and Elan are to end all clinical trials with intravenous bapineuzumab in the treatment of mild-to-moderate Alzheimer's disease. The decision came after the monoclonal antibody, which targets amyloid-beta protein, did not meet the co-primary endpoints of change in cognitive and functional performance in a Janssen-led Phase III clinical trial (Study 301) with patients without the apolipoprotein E epsilon 4 (ApoE4) gene mutation.

Pfizer, Janssen and Elan are to end all clinical trials with intravenous bapineuzumab in the treatment of mild-to-moderate Alzheimer's disease. The decision came after the monoclonal antibody, which targets amyloid-beta protein, did not meet the co-primary endpoints of change in cognitive and functional performance in a Janssen-led Phase III clinical trial (Study 301) with patients without the apolipoprotein E epsilon 4 (ApoE4) gene mutation.

The companies had announced on 23 July that another Janssen-led trial, Study 302 in patients who do have the ApoE4...

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