Is CAR-NK The Natural Successor To CAR-Ts?

 
• By Daniel Chancellor
  
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There is significant commercial potential on offer for the leading CAR-NK developers. While companies committed to continued CAR-T development will need to adapt and innovate in order to remain relevant, especially considering this disruptive new drug class.

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In February 2020, Takeda Pharmaceutical Co. Ltd. became the first company to present clinical data for an emerging class of genetically engineered cell therapies, chimeric antigen receptor (CAR)-directed natural killer (NK) cells. Interim data from a Phase I/IIa trial of Takeda’s anti-CD19 CAR-NK candidate TAK-007 suggested the tantalizing potential that this new modality may substantially improve upon existing CAR-T therapies as a potentially curative standard-of-care for heavily pre-treated patients with hematological malignancies.

The allogeneic nature of TAK-007 could remove many of the manufacturing and logistical hurdles that restrict access to autologous CAR-T...

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