Alvotech Starts European Trial For High-Concentration Adalimumab

 
• By Aidan Fry
  
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Icelandic developer Alvotech is looking to set itself apart from the pack offering biosimilar rivals to Humira by conducting a Phase III clinical trial for an alternative to AbbVie’s high-concentration 100mg/ml version of adalimumab, the world’s best-selling drug.

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Alvotech is studying in plaque psoriasis patients its biosimilar of AbbVie's high-concentration version of Humira • Source: Shutterstock

Alvotech says it has enrolled the first patient in a clinical Phase III study for a biosimilar version of AbbVie’s 100mg/ml high-concentration version of Humira (adalimumab). By offering its AVT02 formulation that has a reduced injection volume, and is thus more convenient for patients, the Icelandic developer believes it will be “well positioned to differentiate from biosimilars competitors”.

Adalimumab 100mg/ml is the Icelandic firm’s lead biosimilar candidate in a pipeline of seven monoclonal antibodies that also includes aflibercept,...

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